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Table 1 Synthesis of the 2-arylidine-1-thia-4-azaspiro[4.5]decan-3-ones (5a–f) using DBSNa (15 mol%)

From: Efficient synthesis and antimicrobial evaluation of some Mannich bases from 2-arylidine-1-thia-4-azaspiro[4.5]decan-3-ones

Entry

Product a

Ar

Time (min)

Yield b (%)

1

5a

Ph

60

94

2

5b

4-ClC6H4

50

96

3

5c

4-BrC6H4

60

93

4

5d

4-O2NC6H4

45

87

5

5e

4-MeOC6H4

40

98

6

5f

4-pyridyl

70

90

  1. a Reaction conditions: 1-thia-4-azaspiro[4.5]decan-3-one (3) (10 mmol), aromatic aldehydes (4a-f) (10 mmol), and DBSNa (20 mol%) in 10 mL acetic acid at room temperature.
  2. b Isolated yields.
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BMC Chemistry

ISSN: 2661-801X

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