Table 1 Structure and IC50 values of type I CDK8 inhibitors
No | Name | Structure | IC50(nM) |
|---|---|---|---|
1 | Cortistatin A |
| 17 |
2 | SEL120-34A |
| 4 |
3 | SenexinA |
| 280 |
4 | SenexinB |
| 24–50 |
5 | CCT251545 |
| 5 |
6 | CCT251921 |
| 2.3 |
7 | 3-Methyl-1H-pyrazolo(3,4-b)pyridine derivative |
| 4.4 |
8 | 1,6-Naphthyridine derivative |
| 5.1 |
9 | Isoquinoline derivative |
| 32.7 |
10 | 3-Benzylindazole derivative |
| 53 |
11 | 6-Azabenzothiophene derivative |
| 1.5 |
12 | BRD6989 |
| \(\approx 500\) |
