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Table 3 Evaluation of the intra-day and inter-day precision of the proposed spectroscopic methods for the determination of ALC and OLO

From: Determination of antihistaminic drugs alcaftadine and olopatadine hydrochloride via ion-pairing with eosin Y as a spectrofluorimetric and spectrophotometric probe: application to dosage forms

Method

Conc. level

% Recovery ± RSDa

 

μg mL−1

Intra-day precision

Inter-day precision

Method A

0.5

100.65 ± 1.84

101.46 ± 1.89

 

1.0

101.61 ± 1.43

100.95 ± 1.73

 

1.5

100.57 ± 1.25

99.82 ± 1.48

Method B

1.0

100.38 ± 1.63

100.72 ± 1.64

 

4.0

101.75 ± 1.19

100.76 ± 1.41

 

6.0

100.11 ± 1.28

99.94 ± 1.01

Method C

0.4

98.11 ± 1.35

99.20 ± 1.40

 

0.8

100.41 ± 1.66

100.03 ± 1.14

 

1.2

100.62 ± 0.78

99.80 ± 1.35

Method D

2.0

101.45 ± 1.00

100.11 ± 1.68

 

6.0

99.35 ± 1.42

98.11 ± 1.26

 

10.0

99.26 ± 1.14

99.33 ± 1.85

  1. aMean of three determination