From: Discovery of dual kinase inhibitors targeting VEGFR2 and FAK: structure-based pharmacophore modeling, virtual screening, and molecular docking studies
Criterion
Cutoff
Lipinski’s rule violation count
≤ 1
 Molecular weight
< 500
 logP
≤ 5
 # HBA
≤ 10
 # HBD
 ≤ 5
Veber’s rule
 Number of rotatable bonds
 Polar surface area
< 140 Å2
LogS
≥  − 5