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Table 1 Antimicrobial activity (MIC and MMC in µg/mL) of extracts, isolated compounds and reference antimicrobial drugs

From: Antimicrobial activities of saponins from Melanthera elliptica and their synergistic effects with antibiotics against pathogenic phenotypes

Extracts/compounds

Inhibition parameters

E. coli

S. flexneri

S. aureus

C. parapsilosis

C. albicans

C. neoformans

MeOH extract

MIC

512

256

128

> 2048

> 2048

> 2048

MMC

1024

512

128

/

/

/

MMC/MIC

2

2

1

/

/

/

n-BuOH extract

MIC

256

128

128

> 2048

> 2048

> 2048

MMC

512

256

128

/

/

/

MMC/MIC

2

2

1

/

/

/

EtOAc extract

MIC

128

128

64

1024

1024

512

MMC

256

128

128

1024

1024

1024

MMC/MIC

2

1

2

1

1

2

1

MIC

32

16

8

32

64

16

MMC

32

32

16

64

64

16

MMC/MIC

1

2

2

2

1

1

2

MIC

32

16

16

> 256

> 256

32

MMC

32

32

16

/

/

64

MMC/MIC

1

2

1

/

/

2

3

MIC

128

64

32

128

128

32

MMC

256

128

64

256

256

64

MMC/MIC

2

2

2

2

2

2

4

MIC

256

128

64

16

16

8

MMC

> 256

256

128

32

64

16

MMC/MIC

/

2

2

2

4

1

Refa

MIC

32

16

0.5

0.5

1

2

MMC

32

16

0.5

0.5

1

2

MMC/MIC

1

1

1

1

1

1

  1. /: not determined; MIC minimum inhibitory concentration, MMC minimum microbicidal concentration
  2. aFluconazole for yeasts and vancomycin for bacteria
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BMC Chemistry

ISSN: 2661-801X

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