From: Targeting matrix metalloproteinases with novel diazepine substituted cinnamic acid derivatives: design, synthesis, in vitro and in silico studies
Compound
Mol. wta
HBAa
HBDa
Log Pa
ΔG (MMP-2)*
ΔG (MMP-9)*
7
409.44
5
3
1.29
− 7.8
− 8.0
8
375.42
0.59
− 7.0
− 7.6
15
425.44
6
4
1.34
− 8.1
− 8.9
16
391.42
0.75
− 7.7