From: Therapeutic potential of heterocyclic pyrimidine scaffolds
Compounds | P. falciparum (IC50 in µM (µg/ml)) | |||
---|---|---|---|---|
P. falciparum (D6) | P. falciparum (W2) | |||
IC50 | SI | IC50 | SI | |
d11 | 4.86 (2.3) | >Â 10.8 | 6.39 (3.02) | >Â 8.2 |
d12 | 2.56 (1.38) | >Â 18 | 3.41 (1.84) | >Â 13.5 |
Artemisinin | < 0.09 (< 0.03) | – | < 0.09 (< 0.03) | – |
Chloroquine | < 0.08 (< 0.03) | – | 0.72 (0.23) | – |