Table 33 In vitro antimalarial activity of AQ-furfural-2-carbaldehyde-pyrimidine hybrids
From: Therapeutic potential of heterocyclic pyrimidine scaffolds
Compound | P. falciparum D6 | P. falciparum W2 | VERO cells | Resistance index | ||
|---|---|---|---|---|---|---|
IC50 (µM) | (SI) | IC50 (µM) | (SI) | |||
d4 | 0.038 ± 0.000 | > 263.15 | 0.040 ± 0.001 | > 250.0 | NC | 1.05 |
Chloroquine | 0.011 ± 0.004 | > 909.09 | 0.317 ± 0.051 | > 31.54 | NC | 28.81 |
Pyrimethamine | 0.009 ± 0.003 | > 1111.1 | NA | – | NC | – |
Artemisinin | 0.045 ± 0.001 | > 222.22 | 0.023 ± 0.001 | 434.78 | NC | 0.511 |