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Table 2 Minimum inhibitory concentrations (MIC) for tested compounds

From: Synthesis, characterization and in vitro antimicrobial activity of novel fused pyrazolo[3,4-c]pyridazine, pyrazolo[3,4-d]pyrimidine, thieno[3,2-c]pyrazole and pyrazolo[3′,4′:4,5]thieno[2,3-d]pyrimidine derivatives

Compounds

Minimum inhibitory concentration (MIC) of the synthesized compounds (µg/mL)

Bacterial species

Fungal species

Escherichia coli

Bacillus subtilis

Bacillus megaterium

Fusarium proliferatum

Trichoderma harzianum

Aspergillus niger

10a

NA

NA

5.10

10.20

25.51

5.10

10b

NA

NA

1.71

21.43

21.43

NA

11a

NA

NA

23.45

46.90

23.45

23.45

11b

14.84

NA

14.84

14.84

29.67

29.67

2

33.47

33.47

33.47

33.47

33.47

5.36

12a

36.22

36.22

5.80

36.22

72.45

NA

12b

29.18

NA

14.59

NA

29.18

NA

8b

87.76

29.20

7.02

43.88

87.76

43.88

3

NA

87.75

NA

5.71

35.71

35.71

5a

NA

NA

NA

35.49

NA

NA

6

NA

71.43

35.71

35.71

NA

NA

9b

54.69

54.69

4.38

4.38

54.69

54.69

13

4.08

10.00

4.08

NA

8.16

8.16

18

58.16

NA

29.08

29.08

29.08

4.65

22a

30.61

NA

NA

30.61

NA

30.61

20

43.47

86.94

43.47

86.94

NA

86.94

23a

NA

83.67

41.84

41.84

NA

6.69

23b

28.78

57.55

4.60

28.78

57.55

4.60

25

66.33

132.65

66.33

132.65

NA

10.61

24

77.14

77.14

6.17

NA

NA

6.17

15

37.96

NA

18.98

NA

37.96

18.98

21

31.84

NA

15.92

NA

NA

15.92

16

47.96

NA

23.98

NA

NA

3.84

14

21.22

21.22

3.40

42.45

42.45

21.22

19

NA

90.20

45.10

7.22

NA

7.22

  1. NA no activity