Table 1 Cytotoxicity of test compounds against HT-1080 cells
From: Synthesis and anticancer activity of novel quinazolinone-based rhodanines
| |||
|---|---|---|---|
Code | R1 | R2 | HT-1080 |
31 | H | H | 42.9 (± 17.3) |
32 | 4-F | H | 47.3 (± 0.3) |
33 | 4-Cl | H | 35.3 (± 4.6) |
34 | 3-Cl | H | 57.1 (± 9.2) |
35 | 4-Br | H | 28.8 (± 2.4) |
36 | 3-Br | H | 43.4 (± 6.7) |
37 | 4-CF3 | H | 15.8 (± 2.1) |
38 | 4-CH3 | H | 35.7 (± 5.9) |
39 | 3-CH3 | H | 47.5 (± 12.1) |
40 | 4-OCH3 | H | 36.4 (± 0.9) |
41 | H | OCH3 | 36.1 (± 2.9) |
42 | 4-F | OCH3 | 35.8 (± 11.8) |
43 | 4-Cl | OCH3 | 10.2 (± 4.7) |
44 | 3-Cl | OCH3 | 28.4 (± 9.4) |
45 | 4-Br | OCH3 | 8.7 (± 3.6) |
46 | 3-Br | OCH3 | 23.7 (± 0.6) |
47 | 4-CF3 | OCH3 | 15.8 (± 2.1) |
48 | 4-CH3 | OCH3 | 31.5 (± 4.1) |
49 | 3-CH3 | OCH3 | 30.7 (± 1.1) |
50 | 4-OCH3 | OCH3 | 34.7 (± 2.7) |
Doxorubicin | – | – | 0.012 (± 0.005) |
