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Table 3 Synthesis of N-propylamides 1016

From: Formation of amides: one-pot condensation of carboxylic acids and amines mediated by TiCl4

Entry

R1

R2

R3

 

Product

Yield (%)a

j

C6H5

H

C3H7

10

91

k

4-NO2–C6H4

H

C3H7

11

92

l

4-CH3O–C6H4

H

C3H7

12

78

m

4-Cl–C6H4

H

C3H7

13

96

n

C6H5CH2

H

C3H7

14

95

o

C6H5CH=CH

H

C3H7

15

97

p

C15H31

H

C3H7

16

94

  1. aIsolated yields