Preparation of a ferulic acid–phospholipid complex to improve solubility, dissolution, and B16F10 cellular melanogenesis inhibition activity

Table 2 Effects of FA and FA–PC cellular melanin content and cell viability in B16F10 melanoma cells

Samples	Concentration (mg/mL)	Cell viability (%)	Cellular melanin content (%)
Control	–	100.00 ± 7.26	100.0 ± 6.6
FA	0.25	104.19 ± 5.88	61.9 ± 8.4**
	0.5	83.31 ± 16.77	48.9 ± 8.0**
	1.0	77.99 ± 7.18	26.5 ± 0.0**
	2.0	12.13 ± 1.91	–
	4.0	11.10 ± 5.01	–
FA–PC	0.25	103.14 ± 7.54	32.4 ± 0.8**^##
	0.5	110.95 ± 7.45	28.0 ± 2.0**^#
	1.0	78.58 ± 9.99	30.3 ± 7.4**
	2.0	71.75 ± 10.12^##	–
	4.0	44.27 ± 7.30^##	–

Data are presented as mean ± SEM of three independent experiments. * P <0.05, ** P <0.01, compared with the control
Data are presented as mean ± SEM of three independent experiments. ^# P <0.05, ^## P <0.01, compared with FA

ISSN: 2661-801X