Compound | IC50 (μM)a | |||||
---|---|---|---|---|---|---|
Hela | HepG2 | HT-29 | MDCK | HY926 | H9C2 | |
1a | 23.67 ± 2.98 | 24.40 ± 1.39 | 22.34 ± 1.75 | 22.63 ± 1.38 | 28.93 ± 1.85 | 46.13 ± 2.01 |
2a | 14.19 ± 1.10 | 22.08 ± 1.18 | 21.72 ± 1.81 | 37.95 ± 1.81 | 27.63 ± 1.84 | >50 |
3a | 24.56 ± 1.72 | 31.99 ± 1.90 | 22.16 ± 2.34 | 22.93 ± 2.43 | >50 | >50 |
4a | 17.53 ± 1.52 | 12.67 ± 1.10 | 14.88 ± 1.80 | 22.24 ± 2.56 | 31.01 ± 1.87 | >50 |
5a | 23.38 ± 1.38 | 31.15 ± 1.34 | 32.99 ± 1.92 | 21.67 ± 1.01 | >50 | 36.14 ± 1.92 |
6a | 22.48 ± 2.08 | 24.36 ± 1.44 | 24.39 ± 1.76 | 33.67 ± 1.40 | 24.99 ± 1.38 | >50 |
7a | 28.01 ± 1.63 | 25.41 ± 1.97 | 26.41 ± 1.96 | >50 | 45.07 ± 2.25 | >50 |
8a | 8.54 ± 1.44 | 21.47 ± 1.50 | 15.02 ± 1.26 | 31.84 ± 2.79 | 27.73 ± 1.39 | >50 |
9a | 30.67 ± 1.89 | 21.88 ± 1.41 | 25.52 ± 1.29 | 27.72 ± 1.08 | 30.79 ± 1.37 | 47.43 ± 1.07 |
1b | 26.92 ± 1.74 | 32.29 ± 1.00 | 28.63 ± 2.99 | 33.33 ± 2.98 | 33.65 ± 3.09 | >50 |
2b | 23.13 ± 2.33 | 33.08 ± 2.09 | 29.34 ± 2.22 | 41.30 ± 1.48 | >50 | 45.75 ± 1.80 |
3b | 22.54 ± 2.16 | 27.31 ± 1.95 | 26.21 ± 1.24 | >30 | 38.46 ± 2.02 | >50 |
4b | 28.69 ± 1.68 | 22.38 ± 1.29 | 22.35 ± 1.2 | >30 | >50 | >50 |
GA | >50 | >50 | >50 | >100 | >100 | >100 |
DPP | 3.76 ± 0.38 | 4.57 ± 0.85 | 5.28 ± 0.74 | 9.97 ± 1.12 | 5.12 ± 0.71 | 5.31 ± 0.26 |