Table 5 Pharmacokinetic parameters of bergapten after oral administration of 5, 10, 15 mg kg−1 (n = 8, mean ± SD)
Parameters | Low (5 mg kg−1) | Medium (10 mg kg−1) | High (15 mg kg−1) |
|---|---|---|---|
Tmax (h) | 3.20 ± 0.45 | 3.88 ± 0.99 | 4.56 ± 1.40 |
Cmax (ng mL−1) | 859.4 ± 253.6 | 1397 ± 573 | 1307 ± 617 |
AUC (0–tn) (ng mL−1 h−1) | 3517 ± 1299 | 8255 ± 3536 | 9197 ± 5790 |
AUC(0–∞) (ng mL−1 h−1) | 3537 ± 1302 | 8266 ± 3534 | 9306 ± 5782 |
V/F (L) | 0.0107 ± 0.0044 | 0.0115 ± 0.0139 | 0.0124 ± 0.0138 |
T1/2α (h) | 9.35 ± 3.07 | 12.88 ± 12.21 | 14.35 ± 15.75 |
MRT(0–tn) (h) | 3.72 ± 0.53 | 4.83 ± 0.47 | 5.57 ± 1.15 |
MRT(0–∞) (h) | 3.91 ± 0.51 | 4.87 ± 0.47 | 6.65 ± 2.27 |