Determination of adapalene in gel formulation by conventional and derivative synchronous fluorimetric approaches. Application to stability studies and in vitro diffusion test

Table 5 Application of the proposed approaches for the determination of adapalene in its pharmaceutical Adapalene^® gel

Parameter	Amount taken (ng/mL)	First approach at 389 nm		Second approach				Comparisonmethod [3]
		Amount found (ng/mL)	% found	Amount found (ng/mL)		% found		Amount found (µg/mL)	% found
		Amount found (ng/mL)	% found	SDSF at 346 nm	FDSF at 312.45 nm	SDSF at 346 nm	FDSF at 312.45 nm	Amount found (µg/mL)	% found
Adapalene^® gel^a	6.0	5.957	99.28	5.932	6.072	98.87	101.20	20.0	100.07
(0.1 % ADP)	8.0	8.082	101.03	7.922	8.026	99.03	100.33	30.0	98.80
Batch # 011371	10.0	10.007	100.07	10.022	9.905	100.22	99.05	40.0	101.03
	12.0	11.900	99.17	11.972	11.986	99.77	99.88
Mean			99.89			99.47	100.12		99.97
S.D.			0.86			0.63	0.90		1.12
t			0.11			0.75	0.19
F			1.69			3.11	1.56

ISSN: 2661-801X