Scheme 3From: Ligustrazinyl amides: a novel class of ligustrazine-phenolic acid derivatives with neuroprotective effects Synthetic routes to ligustrazine derivatives L16. Reagents and Conditions: (i) DMF, benzyl bromide, K2CO3, 85°C, 12 h; (ii) H2O/CH3CH2OH, 10% KOH, 70°C, 2 h; (iii) TMP-NH2, DMF, EDCI/HOBt, r.t., 12 h; (iv) CH3OH, Pd/C, H2, r.t., 12 h.Back to article page