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Table 1 IC 50 values of hydrocarbon and fluorocarbon triazole-linked alkyl β-D-glucopyranosides 4a-g tested on Jurkat cells a

From: Cytotoxic activity of triazole-containing alkyl β-D-glucopyranosides on a human T-cell leukemia cell line

Compound

Alkyl β-D-glucopyranosides b

Control surfactants b

4a

4b

4c

4d

4e

4f

4g

5

C14G1

β-OTG

C7G1

Hydrophobic tail

C 8 H 17

C 10 H 21

C 12 H 25

C 14 H 29

C 16 H 33

C 2 H 4 C 6 F 13

C 2 H 4 C 8 F 17

C 8 H 17

C 14 H 29

C 8 H 17

C 7 H 15

IC 50 value [μM]

1198

171

89

53

24

*

*

663

67

163

*

  1. aThe inhibitory concentration 50% (IC50) in μM is defined as the concentration of experimental compound required to inhibited 50% of the conversion of MTS to formazan, as compared with the absorbance produced by untreated cells after 16 h of incubation.
  2. bPlease see Scheme 1 for the chemical structures and corresponding abbreviations for the alkyl β-D-glucopyranosides and the control surfactants.
  3. *Cytotoxicity was <50% at the highest compound concentration tested (2000 μM) and therefore their IC50 values could not be determined.
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BMC Chemistry

ISSN: 2661-801X

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