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Organic and Medicinal Chemistry

This section publishes articles in all areas of organic chemistry and medicinal chemistry including organic synthesis, bioorganic chemistry, physical organic chemistry, stereochemistry, structure-activity relationships, synthetic methods, organometallic chemistry, supramolecular chemistry, and natural product chemistry.

Section Editors: Vassya Bankova, Bimal Banik

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  1. Content type: Research Article

    The regioselective demethoxylation and dehalogenation of dihalogenated dibenzocyclooctadiene lignans derivatives were realized in a one-step reaction with excellent yields in the sodium and t-butanol reaction sys...

    Authors: Qing-yao Wang, Jia-qi Fang, Lu-lu Deng, Xiao-jiang Hao and Shu-zhen Mu

    Citation: Chemistry Central Journal 2017 11:138

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  2. Content type: Research Article

    A series of 2-(1H-benzo[d]imidazol-2-ylthio)-N-(substituted 4-oxothiazolidin-3-yl) acetamides was synthesized and characterized by physicochemical and spectral means. The synthesized compounds were evaluated for ...

    Authors: Snehlata Yadav, Balasubramanian Narasimhan, Siong M. Lim, Kalavathy Ramasamy, Mani Vasudevan, Syed Adnan Ali Shah and Manikandan Selvaraj

    Citation: Chemistry Central Journal 2017 11:137

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  3. Content type: Research Article

    Dihydrofolate reductase (DHFR) is an important enzyme for de novo synthesis of nucleotides in Plasmodium falciparum and it is essential for cell proliferation. DHFR is a well known antimalarial target for drugs l...

    Authors: Mallika Pathak, Himanshu Ojha, Anjani K. Tiwari, Deepti Sharma, Manisha Saini and Rita Kakkar

    Citation: Chemistry Central Journal 2017 11:132

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  4. Content type: Research article

    Nitroaromatic and chloronitroaromatic compounds have been a subject of great interest in industry and recently in medical-pharmaceutic field. 2-Chloro-4-nitro/2-chloro-5-nitrobenzoic acids and 4-nitrobenzoic a...

    Authors: Manuela Crisan, Liliana Halip, Paulina Bourosh, Sergiu Adrian Chicu and Yurii Chumakov

    Citation: Chemistry Central Journal 2017 11:129

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  5. Content type: Research Article

    Human neutrophil elastase (HNE) is a potent serine protease belonging to the chymotrypsin family and is involved in a variety of pathologies affecting the respiratory system. Thus, compounds able to inhibit HN...

    Authors: Letizia Crocetti, Gianluca Bartolucci, Agostino Cilibrizzi, Maria Paola Giovannoni, Gabriella Guerrini, Antonella Iacovone, Marta Menicatti, Igor A. Schepetkin, Andrei I. Khlebnikov, Mark T. Quinn and Claudia Vergelli

    Citation: Chemistry Central Journal 2017 11:127

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  6. Content type: Research Article

    A simple solvent-free protocol for the preparation of flunixin, a potent non-narcotic, non-steroidal anti-inflammatory drugs is reported using boric acid as catalyst. Its salt, flunixin meglumine are then prep...

    Authors: Mahsa Yarhosseini, Shahrzad Javanshir, Zahra Dolatkhah and Mohammad G. Dekamin

    Citation: Chemistry Central Journal 2017 11:124

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  7. Content type: Research Article

    A series of novel N-(4-methyl-3-((4-(pyridin-3-yl)pyrimidin-2-yl)amino)phenyl)piperidine-4-carboxamide derivatives 10(af), 12(ac) and 14(ac) were synthesized and characterized by FTIR, 1H-NMR, mass spectral an...

    Authors: Vinaya Kambappa, G. K. Chandrashekara, N. D. Rekha, Prasanna D. Shivaramu and Komaraiah Palle

    Citation: Chemistry Central Journal 2017 11:122

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  8. Content type: Research Article

    Lesinurad is an oral inhibitor of urate-anion exchanger transporter 1 and has been approved by the US Food and Drug Administration for combination therapy with a xanthine oxidase inhibitor for the treatment of...

    Authors: Xiao-Yang Zhou, Ling-Jing Yuan, Zhe Chen, Peng-Fei Tang, Xiang-Yu Li, Guo-Xin Hu and Jian-Ping Cai

    Citation: Chemistry Central Journal 2017 11:121

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  9. Content type: Research article

    A series of recently reported phenolic azo dyes 7a–e were prepared by coupling the thienyl diazonium sulfate of 3-Amino-4H-benzo[f]thieno[3,4-c](2H)chromen-4-one with selected diversely substituted phenolic and n...

    Authors: Joseph Tsemeugne, Emmanuel Sopbué Fondjo, Jean-de-Dieu Tamokou, Ignas Tonle, Irene Chinda Kengne, Arnaud Djintchui Ngongang, Stephen Tamekou Lacmata, Taoufik Rohand, Jules Roger Kuiate and Beibam Luc Sondengam

    Citation: Chemistry Central Journal 2017 11:119

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  10. Content type: Research article

    Polysaccharides are structurally complex and essential constituents of life, and therefore, studies directed to these kinds of molecules have received scientific attention. Despite an easy availability of Dolicho...

    Authors: Shibani Basu, Manojit Ghosh, Rupam Kumar Bhunia, Jhuma Ganguly and Bimal K. Banik

    Citation: Chemistry Central Journal 2017 11:118

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  11. Content type: Research article

    The plant Alisma plantago-aquatica Linnaeus, which is widely distributed in southwest of China, is the main material of traditional Chinese medicine “Zexie”. It was used as folk medicine for immune-modulation, an...

    Authors: Ya-sheng Huang, Qi-qi Yu, Yin Chen, Min-jie Cheng and Li-ping Xie

    Citation: Chemistry Central Journal 2017 11:120

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  12. Content type: Research article

    The interaction of paeoniflorin with human serum albumin (HSA) was investigated using fluorescence, UV–vis absorption, circular dichroism (CD) spectra and molecular docking techniques under simulative physiolo...

    Authors: Liang Xu, Yan-Xi Hu, Yan-Cheng Li, Yu-Feng Liu, Li Zhang, Hai-Xin Ai and Hong-Sheng Liu

    Citation: Chemistry Central Journal 2017 11:116

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  13. Content type: Research article

    Acyl hydrazones are an important class of heterocyclic compounds promising pharmacological characteristics. Malaria is a life-threatening mosquito-borne blood disease caused by a plasmodium parasite. In some p...

    Authors: Parvin Kumar, Kulbir Kadyan, Meenakshi Duhan, Jayant Sindhu, Vineeta Singh and Baljeet Singh Saharan

    Citation: Chemistry Central Journal 2017 11:115

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    The Correction to this article has been published in Chemistry Central Journal 2018 12:9

  14. Content type: Research article

    Many Geum species are known to be rich in biologically active compounds and therefore could be a source of new natural products with pharmacological potential. The medicinal plant Geum urbanum L. is widespread in...

    Authors: Lyudmila Dimitrova, Maya M. Zaharieva, Milena Popova, Nedelina Kostadinova, Iva Tsvetkova, Vassya Bankova and Hristo Najdenski

    Citation: Chemistry Central Journal 2017 11:113

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  15. Content type: Research article

    Some novel substituted pyrazolone, pyrazolo[3,4-c]pyridazine, pyrazolo[3,4-d]pyrimidine, pyrazolo[3,4-d]thiazolo[3,2-a]pyrimidinone, thieno[3,2-c]pyrazole and pyrazolo[3′,4′:4,5]thieno[2,3-d]pyrimidine derivative...

    Authors: Mohamed A. M. Abdel Reheim and Safaa M. Baker

    Citation: Chemistry Central Journal 2017 11:112

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    The Correction to this article has been published in Chemistry Central Journal 2017 11:123

  16. Content type: Research article

    This work compares the composition at different temperatures of gaseous phase of bergamot essential oil at equilibrium with the liquid phase. A new GC–MS methodology to determine quantitatively the volatile ar...

    Authors: Antonella Leggio, Vanessa Leotta, Emilia Lucia Belsito, Maria Luisa Di Gioia, Emanuela Romio, Ilaria Santoro, Domenico Taverna, Giovanni Sindona and Angelo Liguori

    Citation: Chemistry Central Journal 2017 11:111

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  17. Content type: Research article

    Myricetin and 1,3,4-thiadiazole derivatives were reported to exhibit favorable antiviral and antibacterial activities. Aiming to discover novel myricetin analogues with potent activities, a series of novel myr...

    Authors: Xinmin Zhong, Xiaobin Wang, Lijuan Chen, Xianghui Ruan, Qin Li, Juping Zhang, Zhuo Chen and Wei Xue

    Citation: Chemistry Central Journal 2017 11:106

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  18. Content type: Research article

    Many heterocyclic compounds containing thiazole or 1,3,4-thiadiazole ring in their skeletons have been reported to possess various pharmacological activities especially anticancer activities.

    Authors: Sobhi M. Gomha, Mohamad R. Abdelaziz, Nabila A. Kheder, Hassan M. Abdel-aziz, Seham Alterary and Yahia N. Mabkhot

    Citation: Chemistry Central Journal 2017 11:105

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  19. Content type: Research Article

    In this study, Ligustrum lucidum flowers as raw material, the extraction, isolation and coagulatory activity of polysaccharides were carried out for the first time. The crude polysaccharide was obtained by hot wa...

    Authors: Zhenhua Yin, Wei Zhang, Juanjuan Zhang and Wenyi Kang

    Citation: Chemistry Central Journal 2017 11:98

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  20. Content type: Research article

    12N-benzyl matrinic acid analogues had been identified to be a novel scaffold of anti-HCV agents with a specific mechanism, and the representative compound 1 demonstrated a moderate anti-HCV activity. The intensi...

    Authors: Sheng Tang, Zong-Gen Peng, Ying-Hong Li, Xin Zhang, Tian-Yun Fan, Jian-Dong Jiang, Yan-Xiang Wang and Dan-Qing Song

    Citation: Chemistry Central Journal 2017 11:94

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  21. Content type: Research article

    Lesinurad is a novel selective uric acid salt transport protein 1 (URAT1) inhibitor which is approved in the USA for the treatment of gout. However, there are some shortcomings among the reported synthetic rou...

    Authors: Qing Meng, Tong Zhao, Dongwei Kang, Boshi Huang, Peng Zhan and Xinyong Liu

    Citation: Chemistry Central Journal 2017 11:86

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  22. Content type: Research article

    A series of six novel benzimidazole-pyrazole hybrid molecules was synthesized and characterized using elemental analysis (CHN) and spectroscopic methods (1HNMR, FT-IR). All the synthesized compounds were evaluate...

    Authors: Abida Noor, Neelum Gul Qazi, Humaira Nadeem, Arif-ullah Khan, Rehan Zafar Paracha, Fawad Ali and Adil Saeed

    Citation: Chemistry Central Journal 2017 11:85

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  23. Content type: Research article

    Suoyang originates from a psammophyte named Cynomorium songaricum Rupr and has been known as a phenolic-antioxidant-enriched traditional Chinese herbal medicine. The present study atte...

    Authors: Yulu Xie, Xican Li, Jieying Xu, Qian Jiang, Hong Xie, Jianfeng He and Dongfeng Chen

    Citation: Chemistry Central Journal 2017 11:84

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  24. Content type: Research article

    Radezolid (RAD, 12), biaryl oxazolidinone, was synthesised with small modifications according to the methods described in the literature. The pharmacological activity is observed only for (S)-enantiomer, therefor...

    Authors: Katarzyna Michalska, Elżbieta Bednarek, Ewa Gruba, Kornelia Lewandowska, Mikołaj Mizera and Judyta Cielecka-Piontek

    Citation: Chemistry Central Journal 2017 11:82

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  25. Content type: Research article

    Typically, oxazolinyl metal complexes are synthesized in two steps, where the free ligand is prepared by the condensation reaction between a functionalized nitrile and an amino alcohol in the presence of a Lew...

    Authors: Mei Luo, Jing Cheng Zhang, Wen Min Pang and King Kuok Hii

    Citation: Chemistry Central Journal 2017 11:81

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    The Erratum to this article has been published in Chemistry Central Journal 2017 11:91

  26. Content type: Research article

    In the past few years, increased resistance of microorganisms towards antimicrobial agents become a serious health problem, so there is a need for the discovery of new antimicrobial agents. On the other hand, ...

    Authors: Sanjiv Kumar, Siong Meng Lim, Kalavathy Ramasamy, Mani Vasudevan, Syed Adnan Ali Shah and Balasubramanian Narasimhan

    Citation: Chemistry Central Journal 2017 11:80

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  27. Content type: Research article

    Two new symmetrical bis-thiourea, 2,2′-[{(terephthaloylbis(azanediyl)bis(carbonothioyl) bis(azanediyl)}dipropanoic acid] (1A) and 3,3′-[{(terephthaloylbis(azanediyl)bis (carbonothioyl)bis(azanediyl)} dipropano...

    Authors: Imran Fakhar, Bohari M. Yamin and Siti Aishah Hasbullah

    Citation: Chemistry Central Journal 2017 11:76

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  28. Content type: Research article

    The thiophene nucleus has been recognized as an important entity in the synthesis of heterocyclic compounds with promising pharmacological characteristics.

    Authors: Yahia Nasser Mabkhot, Nahed Ahmed Kaal, Seham Alterary, Salem S. Al-Showiman, Thoraya A. Farghaly and Mohammad S. Mubarak

    Citation: Chemistry Central Journal 2017 11:75

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  29. Content type: Research article

    Synthesis of 6-isomer of 5,8-O-dimethyl ether of shikonin (13), a promising anticancer scaffold, always remains a huge challenge. Herein a key intermediate for 13, 2-(1-hydroxyl-4-methyl-3-pentenyl)-1,4,5,8-tetra...

    Authors: Li Zhou, Xu Zhang and Wen Zhou

    Citation: Chemistry Central Journal 2017 11:74

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  30. Content type: Research article

    Tumor angiogenesis, essential for tumor growth and metastasis, is tightly regulated by VEGF/VEGFR and PDGF/PDGFR pathways, and therefore blocking those pathways is a promising therapeutic target. Compared to s...

    Authors: Ting-Hsuan Yang, Chun-I Lee, Wen-Hsin Huang and An-Rong Lee

    Citation: Chemistry Central Journal 2017 11:72

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  31. Content type: Research article

    Uracil derivatives have a great attraction because they play an important role in pharmacological activities. Pyrimidodiazepines, lumazines, triazolopyrimidines and xanthines have significant wide spectrum act...

    Authors: Samar A. El-Kalyoubi, Eman A. Fayed and Ahmed S. Abdel-Razek

    Citation: Chemistry Central Journal 2017 11:66

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    The Erratum to this article has been published in Chemistry Central Journal 2017 11:69

  32. Content type: Methodology

    Experimental approaches for determining the metabolic properties of the drug candidates are usually expensive, time-consuming and labor intensive. There is a great deal of interest in developing computational ...

    Authors: Jiajia Meng, Shiliang Li, Xiaofeng Liu, Mingyue Zheng and Honglin Li

    Citation: Chemistry Central Journal 2017 11:65

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  33. Content type: Research article

    Pyrazolo[1,5-a]pyrimidines are purine analogues. They have beneficial properties as antimetabolites in purine biochemical reactions. This division compounds have attracted wide pharmaceutical interest because of ...

    Authors: Nadia A. Abdelriheem, Yasser H. Zaki and Abdou O. Abdelhamid

    Citation: Chemistry Central Journal 2017 11:53

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  34. Content type: Research article

    Due to their interesting and versatile biological activity, thiophene-containing compounds have attracted the attention of both chemists and medicinal chemists. Some of these compounds have anticancer, antibac...

    Authors: Yahia N. Mabkhot, Salim S. Al-Showiman, Saied M. Soliman, Hazem A. Ghabbour, Murad A. AlDamen and Mohammad S. Mubarak

    Citation: Chemistry Central Journal 2017 11:51

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  35. Content type: Research article

    The diacylhydrazine derivatives have attracted considerable attention in recently years due to their simple structure, low toxicity, and high insecticidal selectivity. As well as 3-bromo-1-(3-chloropyridin-2-y...

    Authors: Yanyan Wang, Fangzhou Xu, Gang Yu, Jun Shi, Chuanhui Li, A’li Dai, Zhiqian Liu, Jiahong Xu, Fenghua Wang and Jian Wu

    Citation: Chemistry Central Journal 2017 11:50

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  36. Content type: Research article

    A series of novel N-(2, 6-dimethoxypyrimidin-4-yl)-4-(3-(aryl)thioureido) benzenesulfonamides 3at was synthesized by the addition of N-(2,6-dimethoxypyrimidin-4-yl)-4-isothiocyanatobenzenesulfonamide 2 to the ap...

    Authors: Mostafa M. Ghorab, Mohamed S. A. El-Gaby, Aiten M. Soliman, Mansour S. Alsaid, Marwa M. Abdel-Aziz and Mahmoud M. Elaasser

    Citation: Chemistry Central Journal 2017 11:42

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  37. Content type: Research article

    Quantitative structure activity relationship was carried out to study a series of PIM1 and PIM2 inhibitors. The present study was performed on twenty-five substituted 5-(1H-indol-5-yl)-1,3,4-thiadiazols as PIM...

    Authors: Adnane Aouidate, Adib Ghaleb, Mounir Ghamali, Samir Chtita, M’barek Choukrad, Abdelouahid Sbai, Mohammed Bouachrine and Tahar Lakhlifi

    Citation: Chemistry Central Journal 2017 11:41

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  38. Content type: Research article

    Replacement of chloride ions in cyanuric chloride give several variants of 1,3,5-triazine derivatives which were investigated as biologically active small molecules. These compounds exhibit antimalarial, antim...

    Authors: Khadijah M. Al-Zaydi, Hosam H. Khalil, Ayman El-Faham and Sherine N. Khattab

    Citation: Chemistry Central Journal 2017 11:39

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  39. Content type: Research article

    Various thiourea derivatives have been used as starting materials for compounds with better biological activities. Molecular modeling tools are used to explore their mechanism of action.

    Authors: Mostafa M. Ghorab, Mansour S. Alsaid, Mohamed S. A. El-Gaby, Mahmoud M. Elaasser and Yassin M. Nissan

    Citation: Chemistry Central Journal 2017 11:32

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  40. Content type: Research article

    A series of rare-earth bisphthalocyanines of praseodymium, samarium and gadolinium bearing 5-bromo-2-thienyl substituents were prepared for the first time.

    Authors: Jiří Černý, Lenka Dokládalová, Petra Horáková, Antonín Lyčka, Tomáš Mikysek and Filip Bureš

    Citation: Chemistry Central Journal 2017 11:31

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  41. Content type: Research article

    Cancer is one of the leading causes of death and only second to heart diseases. Recently, preclinical studies have demonstrated that curcumin had a number of anticancer properties. Thus, we planned to synthesi...

    Authors: Hui Luo, Shengjie Yang, Da Hong, Wei Xue and Pu Xie

    Citation: Chemistry Central Journal 2017 11:23

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  42. Content type: Research article

    The aim of this study is the development of nanoemulsions for intravenous administration of Sorafenib, which is a poorly soluble drug with no parenteral treatment. The formulation was prepared by a high energy...

    Authors: Zahra Izadiyan, Mahiran Basri, Hamid Reza Fard Masoumi, Roghayeh Abedi Karjiban, Norazlinaliza Salim and Kamyar Shameli

    Citation: Chemistry Central Journal 2017 11:21

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