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Biological Chemistry

This section publishes peer-reviewed open access articles in all areas of biologically- and medically-related chemistry including biochemistry, chemical biology, biotechnology, biomacromolecules, medicinal chemistry, carbohydrate chemistry, and toxicology.

Note: As of 2018, this section is being re-launched as Chemical Biology. Whilst the Section page is under development, readers can find out more about the scope and editors of this section here.

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  1. Content type: Research Article

    Ricinus communis (castor plant) is a potent medicinal plant, which is commonly used in the treatment of various ailments. The present study was conducted to appraise the cytotoxicity and mutagenicity of R. commun...

    Authors: Mazhar Abbas, Abid Ali, Muhammad Arshad, Asia Atta, Zahed Mehmood, Imtiaz Mahmood Tahir and Munawar Iqbal

    Citation: Chemistry Central Journal 2018 12:3

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  2. Content type: Research article

    This study focused on maximizing the extraction yield of total phenolics and flavonoids from Curcuma Zedoaria leaves as a function of time (80–120 min), temperature (60–80 °C) and ethanol concentration (70–90 v/v...

    Authors: Nur Fauwizah Azahar, Siti Salwa Abd Gani and Nor Fadzillah Mohd Mokhtar

    Citation: Chemistry Central Journal 2017 11:96

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  3. Content type: Review

    The sunflower (Helianthus annuus L.) seed and sprout is a ubiquitous crop with abundant nutrients and biological activities. This review summarizes the nutritional and medical importance currently recognized but ...

    Authors: Shuangshuang Guo, Yan Ge and Kriskamol Na Jom

    Citation: Chemistry Central Journal 2017 11:95

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  4. Content type: Research article

    The crystal structure of a commercially available form of human recombinant (HR) insulin, Insugen (I), used in the treatment of diabetes has been determined to 0.92 Å resolution using low temperature, 100 K, s...

    Authors: David R. Lisgarten, Rex A. Palmer, Carina M. C. Lobley, Claire E. Naylor, Babur Z. Chowdhry, Zakieh I. Al-Kurdi, Adnan A. Badwan, Brendan J. Howlin, Nicholas C. J. Gibbons, José W. Saldanha, John N. Lisgarten and Ajit K. Basak

    Citation: Chemistry Central Journal 2017 11:73

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  5. Content type: Research article

    Developing an efficient lipophilization reaction system for phenolic derivatives could enhance their applications in food processing. Low solubility of phenolic acids reduces the efficiency of phenolic derivat...

    Authors: Somayeh Gholivand, Ola Lasekan, Chin Ping Tan, Faridah Abas and Leong Sze Wei

    Citation: Chemistry Central Journal 2017 11:44

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  6. Content type: Preliminary communication

    Plants contain a myriad of metabolites which exhibit diverse biological activities. However, in-depth analyses of these natural products with current analytical platforms remains an undisputed challenge due to...

    Authors: Keabetswe Masike, Msizi I. Mhlongo, Shonisani P. Mudau, Ofentse Nobela, Efficient N. Ncube, Fidele Tugizimana, Mosotho J. George and Ntakadzeni E. Madala

    Citation: Chemistry Central Journal 2017 11:29

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  7. Content type: Research article

    Litchi (Litchi chinensis Sonn.) is a subtropical fruit with attractive characteristic of white to creamy semitranslucent flesh and red color in pericap, but it was easily subjected to the infection of Peronophyth...

    Authors: Hai Liu, Guoxing Jing, Yueming Jiang, Fuying Luo and Zaifeng Li

    Citation: Chemistry Central Journal 2017 11:14

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  8. Content type: Research Article

    The antibacterial activity of 21 nm TiO2 nanoparticles (NPs) and particles modified with Garcinia zeylanica (G. zeylanica) against Methicillin resistant Staphylococcus aureus was investigated in the presence and ...

    Authors: U. L. N. H. Senarathna, S. S. N. Fernando, T. D. C. P. Gunasekara, M. M. Weerasekera, H. G. S. P. Hewageegana, N. D. H. Arachchi, H. D. Siriwardena and P. M. Jayaweera

    Citation: Chemistry Central Journal 2017 11:7

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  9. Content type: Research article

    Glomerular filtration rate (GFR) is usually determined by estimation of iothalamate (IOT) clearance. We have developed and validated an accurate and robust method for the analysis of IOT in human plasma and ur...

    Authors: Iltaf Shah, James Barker, Declan P. Naughton, Stephen J. Barton and Syed Salman Ashraf

    Citation: Chemistry Central Journal 2016 10:80

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  10. Content type: Research article

    A protein, Tm1631 from the hyperthermophilic organism Thermotoga maritima belongs to a domain of unknown function protein family. It was predicted that Tm1631 binds with the DNA and that the Tm1631–DNA complex is...

    Authors: Mitja Ogrizek, Janez Konc, Urban Bren, Milan Hodošček and Dušanka Janežič

    Citation: Chemistry Central Journal 2016 10:41

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  11. Content type: Research Article

    Phenoxazinone synthase (PHS) is a laccase-like multicopper oxidase originating from Streptomyces with great industrial application potential. In this paper, we prepared the PHS nanogel retaining 82 % of its initi...

    Authors: Honghua Jia, Zhen Gao, Yingying Ma, Chao Zhong, Chunming Wang, Hua Zhou and Ping Wei

    Citation: Chemistry Central Journal 2016 10:34

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  12. Content type: Methodology

    Volatile organic compounds (VOCs) can be intermediates of metabolic pathways and their levels in biological samples may provide a better understanding about diseases in addition to potential methods for diagno...

    Authors: Raphael B. M. Aggio, Arno Mayor, Séamus Coyle, Sophie Reade, Tanzeela Khalid, Norman M. Ratcliffe and Chris S. J. Probert

    Citation: Chemistry Central Journal 2016 10:9

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  13. Content type: Review

    Age-associated neurodegenerative disorders such as Alzheimer’s disease are a major public health challenge, due to the demographic increase in the proportion of older individuals in society. However, the relat...

    Authors: Xi Chen, Jeff W. Barclay, Robert D. Burgoyne and Alan Morgan

    Citation: Chemistry Central Journal 2015 9:65

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  14. Content type: Research article

    Chlorogenic acids (CGAs) are a class of phytochemicals that are formed as esters between different derivatives of cinnamic acid and quinic acid molecules. In plants, accumulation of these compounds has been li...

    Authors: Efficient N Ncube, Msizi I Mhlongo, Lizelle A Piater, Paul A Steenkamp, Ian A Dubery and Ntakadzeni E Madala

    Citation: Chemistry Central Journal 2014 8:66

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  15. Content type: Research article

    Zanthoxylum buesgenii is a shrub used in Sierra Leone as remedy to cure venereal diseases, arthritis, and rheumatism whereas leaves and barks are employed to treat leprosy and to relieve pain. In South West Regio...

    Authors: Louis P Sandjo, Victor Kuete, Rodrigue S Tchangna, Thomas Efferth and Bonaventure T Ngadjui

    Citation: Chemistry Central Journal 2014 8:61

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  16. Content type: Erratum

    This is a correction to the following paper: General peroxidase activity of a parallel G-quadruplex-hemin DNAzyme formed by Pu39WT - a mixed G-quadruplex forming sequence in the Bcl-2 P1 promoter, Bo Liu, Da L...

    Authors: Bo Liu, Hong Shang and Da Li

    Citation: Chemistry Central Journal 2014 8:57

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    The original article was published in Chemistry Central Journal 2014 8:43

  17. Content type: Mini review

    Advances in biomedical science are leading to upsurge synthesis of nanodelivery systems for drug delivery. The systems were characterized by controlled, targeted and sustained drug delivery ability. Humans are...

    Authors: Aminu Umar Kura, Sharida Fakurazi, Mohd Zobir Hussein and Palanisamy Arulselvan

    Citation: Chemistry Central Journal 2014 8:46

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  18. Content type: Research article

    A 39-base-pair sequence (Pu39WT) located 58 to 19 base pairs upstream of the Bcl-2 P1 promoter has been implicated in the formation of an intramolecular mixed G-quadruplex structure and is believed to play a m...

    Authors: Bo Liu, Da Li and Hong Shang

    Citation: Chemistry Central Journal 2014 8:43

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    The Erratum to this article has been published in Chemistry Central Journal 2014 8:57

  19. Content type: Research article

    Chalcone, an important intermediate of flavonoid synthetic pathway, has been shown to exhibit diverse biological and pharmacological activities such as anti- cancer, antioxidant, anti-inflammatory, etc.

    Authors: Siham Abdelrahmane Lahsasni, Faeza Hamad Al Korbi and Nabilah Abdel-Aziz Aljaber

    Citation: Chemistry Central Journal 2014 8:32

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  20. Content type: Research article

    Locked nucleic acid (LNA) and 2'–O-methyl nucleic acid (OMeNA) are two of the most extensively studied nucleotide derivatives in the last decades. However, how they affect DNA quadruplex structures remains largel...

    Authors: Bo Liu and Da Li

    Citation: Chemistry Central Journal 2014 8:19

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  21. Content type: Research article

    Current study has been designed to estimate the possible antioxidant, antimicrobial and hemolytic potential of Ficus benjamina different parts (leaves, stem and root).

    Authors: Muhammad Imran, Nasir Rasool, Komal Rizwan, Muhammad Zubair, Muhammad Riaz, Muhammad Zia-Ul-Haq, Usman Ali Rana, Ayman Nafady and Hawa ZE Jaafar

    Citation: Chemistry Central Journal 2014 8:12

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  22. Content type: Research article

    A large number of essential oils is reported to have significant activity against Candida albicans. But the different chemical composition influences the degree of their activity. The intention of this study was ...

    Authors: Diana Obistioiu, Romeo T Cristina, Ivo Schmerold, Remigius Chizzola, Klaus Stolze, Ileana Nichita and Viorica Chiurciu

    Citation: Chemistry Central Journal 2014 8:6

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  23. Content type: Research article

    Several quinazoline and triazole derivatives are reported to possess a wide-range of interesting pharmacological effects. Although various triazoloquinazoline subclasses having been synthesized and studied, th...

    Authors: Rashad Al-Salahi, Kamal-Eldin El-Tahir, Ibrahim Alswaidan, Nabih Lolak, Mohammed Hamidaddin and Mohamed Marzouk

    Citation: Chemistry Central Journal 2014 8:3

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  24. Content type: Research article

    D-isoascorbic acid is a food antioxidant additive and used in accordance with Good Manufacturing Practice (GMP). High solubility in water (about 150 g/L at 25°C) reduces its effectiveness in stabilizing fats a...

    Authors: Feng-Jie Cui, Hong-Xia Zhao, Wen-Jing Sun, Zhuan Wei, Si-Lian Yu, Qiang Zhou and Ying Dong

    Citation: Chemistry Central Journal 2013 7:180

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  25. Content type: Research article

    Combretastatin A-4 (CA-4), which is an excellent antineoplastic agent, was isolated from Combretum caffrum. To date, structural modification studies of CA-4 have focused predominantly on the construction of new t...

    Authors: Mingyi Ma, Longru Sun, Hongxiang Lou and Mei Ji

    Citation: Chemistry Central Journal 2013 7:179

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  26. Content type: Research article

    Drugs that bind to the human Ether-a-go-go Related Gene (hERG) potassium channel and block its ion conduction can lead to Torsade de Pointes (TdP), a fatal ventricular arrhythmia. Thus, compounds are screened ...

    Authors: Clayton Springer and Katherine L Sokolnicki

    Citation: Chemistry Central Journal 2013 7:167

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  27. Content type: Research article

    Plant Biotransformation is one of the tools for structural modifications of the organic substrate of low, moderate or high biological value utilizing plant cultured cells, these modifications of organic struct...

    Authors: Saifullah, Saifullah Khan, Azizuddin, Sobia Ahsan Halim, Muhammad Kashif, Almas Jabeen, Muhmammad Asif, Muhammad Ahmed Mesaik, Zaheer Ul-Haq, Ahsana Dar and Muhammad Iqbal Choudhary

    Citation: Chemistry Central Journal 2013 7:163

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  28. Content type: Research article

    Flos Genkwa (yuanhua in Chinese), the dried flower buds of Daphne genkwa Zucc. (Thymelaeaceae), is a traditional Chinese medicinal herb mainly used for diuretic, antitussive, expectorant, and anticancer e...

    Authors: Simeng Li, Guixin Chou, Youcheng Hseu, Hsinling Yang, HiuYee Kwan and Zhiling Yu

    Citation: Chemistry Central Journal 2013 7:159

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  29. Content type: Review

    The resinous metabolites commonly known as frankincense or olibanum are produced by trees of the genus Boswellia and have attracted increasing popularity in Western countries in the last decade for their various ...

    Authors: Yuxin Zhang, Zhangchi Ning, Cheng Lu, Siyu Zhao, Jianfen Wang, Baoqin Liu, Xuegong Xu and Yuanyan Liu

    Citation: Chemistry Central Journal 2013 7:153

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  30. Content type: Research article

    During ageing an altered redox balance has been observed in both intracellular and extracellular compartments, primarily due to glutathione depletion and metabolic stress. Maintaining redox homeostasis is impo...

    Authors: Rita Barreto Duarte Carilho Torrao, Irundika HK Dias, Stuart J Bennett, Christopher R Dunston and Helen R Griffiths

    Citation: Chemistry Central Journal 2013 7:150

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  31. Content type: Research article

    Zanthoxylum zanthoxyloides and Z. leprieurii fruits are commonly used in traditional system of medicine for diarrhea, pain, wound healing, etc. in Cameroon, Africa. Z. leprieurii fruits have been chemically studi...

    Authors: Vyry NA Wouatsa, Laxminarain Misra, Shiv Kumar, Om Prakash, Feroz Khan, Francois Tchoumbougnang and R Kumar Venkatesh

    Citation: Chemistry Central Journal 2013 7:125

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  32. Content type: Review

    In China, several species (Hedysarum polybotrys Hand.-Mazz., Hedysarum limprichtii Hlbr., Hedysarum vicioider Turcz. var. Taipeicum Hand.-Mazz. Liu, Hedysarum smithianum, et al.) of genus Hedysarum have a long hi...

    Authors: Yinmao Dong, Dongyan Tang, Na Zhang, Yue Li, Chunhong Zhang, Li Li and Minhui Li

    Citation: Chemistry Central Journal 2013 7:124

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  33. Content type: Research article

    A label-free immunosensor from as-grown double wall carbon nanotubes (DW) bundles was developed for detecting Salmonella typhimurium. The immunosensor was fabricated by using the as-grown DW bundles as an electro...

    Authors: Niramol Punbusayakul, Saikat Talapatra, Pulickel M Ajayan and Werasak Surareungchai

    Citation: Chemistry Central Journal 2013 7:102

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  34. Content type: Research article

    The goal of this study has been to evaluate the extent of mycotoxins contamination and their co-occurrence in wheat grain intended for animal feed. A total of 52 wheat samples were collected from the harvest o...

    Authors: Ersilia Alexa, Cristina Adriana Dehelean, Mariana-Atena Poiana, Isidora Radulov, Anca-Maria Cimpean, Despina-Maria Bordean, Camelia Tulcan and Georgeta Pop

    Citation: Chemistry Central Journal 2013 7:99

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  35. Content type: Research article

    Isoniazid (INH) is front-line anti-tuberculosis (TB) drugs, which are usually prescribed to TB patients for a total period of 6 months. Antituberculosis drug-induced hepatotoxicity (ATDH) is a serious adverse ...

    Authors: Nana Du, Liangquan Sheng, Zhaodi Liu, Xiaojuan Hu, Huajie Xu and Shuisheng Chen

    Citation: Chemistry Central Journal 2013 7:97

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  36. Content type: Research article

    Cancer is a severe threat to the human society. In the scientific community worldwide cancer remains a big challenge as there are no remedies as of now. Cancer is quite complicated as it involves multiple sign...

    Authors: Biswadip Banerji, Sumit Kumar Pramanik, Uttam Pal and Nakul Chandra Maiti

    Citation: Chemistry Central Journal 2013 7:91

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  37. Content type: Research article

    For screening a library of enzyme mutants, an efficient and cost-effective method for reliable assay of enzyme activity and a decision method for safe recognition of mutants of higher activity are needed. The ...

    Authors: Juan Feng, Hongbo Liu, Xiaolan Yang, Ang Gao, Juan Liao, Liping Feng, Jun Pu, Yanling Xie, Gaobo Long, Yuanli Li and Fei Liao

    Citation: Chemistry Central Journal 2013 7:69

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  38. Content type: Research article

    Coumarin and its derivatives are biologically very active. It was found that the enhanced activities are dependent on the coumarin nucleus. Biological significance of these compounds include anti-bacterial, an...

    Authors: Sadia Rehman, Muhammad Ikram, Robert J Baker, Muhammad Zubair, Effat Azad, Soyoung Min, Kashif Riaz, KH Mok and Saeed-Ur Rehman

    Citation: Chemistry Central Journal 2013 7:68

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  39. Content type: Research article

    Phenolic compounds are widely distributed in plant kingdom and constitute one of the most important classes of natural and synthetic antioxidants. In the present study fifty one natural and synthetic structura...

    Authors: Hussein M Ali, Ahmed Abo-Shady, Hany A Sharaf Eldeen, Hany A Soror, Wafaa G Shousha, Osama A Abdel-Barry and Ahmed M Saleh

    Citation: Chemistry Central Journal 2013 7:53

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  40. Content type: Research article

    Cigarette smoking is a cause of a variety of serious diseases, and to understand the toxicological impact of tobacco smoke in vitro, whole smoke exposure systems can be used. One of the main challenges of the dif...

    Authors: Jason Adamson, David Thorne, Annette Dalrymple, Debbie Dillon and Clive Meredith

    Citation: Chemistry Central Journal 2013 7:50

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  41. Content type: Research article

    Mycobacterium tuberculosis (M.tb) is the causative agent of tuberculosis, killing ~1.7 million people annually. The remarkable capacity of this pathogen to escape the host immune system for decades and then to ca...

    Authors: Deepak Singla, Rupinder Tewari, Ashwani Kumar and Gajendra PS Raghava

    Citation: Chemistry Central Journal 2013 7:49

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  42. Content type: Research article

    The witches’ broom disease is a plague caused by Moniliophthora perniciosa in the Theobroma cacao, which has been reducing the cocoa production since 1989. This issue motivated a genome project that has showing s...

    Authors: Manoelito C Santos Junior, Sandra Aparecida de Assis, Aristóteles Góes-Neto, Ângelo Amâncio Duarte, Ricardo José Alves, Moacyr Comar Junior and Alex Gutterres Taranto

    Citation: Chemistry Central Journal 2013 7:48

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  43. Content type: Research article

    Among the 20 natural amino acids histidine is the most active and versatile member that plays the multiple roles in protein interactions, often the key residue in enzyme catalytic reactions. A theoretical and ...

    Authors: Si-Ming Liao, Qi-Shi Du, Jian-Zong Meng, Zong-Wen Pang and Ri-Bo Huang

    Citation: Chemistry Central Journal 2013 7:44

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  44. Content type: Review

    The dipeptide carnosine (β-alanyl-L-histidine) has contrasting but beneficial effects on cellular activity. It delays cellular senescence and rejuvenates cultured senescent mammalian cells. However, it also in...

    Authors: Alan R Hipkiss, Stephanie P Cartwright, Clare Bromley, Stephane R Gross and Roslyn M Bill

    Citation: Chemistry Central Journal 2013 7:38

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  45. Content type: Research article

    In the last years essential oils from different plants were used in the prevention of fungi and mycotoxins accumulation in cereals. The most attractive aspect derived from using of essential oils as seed grain...

    Authors: Renata-Maria Sumalan, Ersilia Alexa and Mariana-Atena Poiana

    Citation: Chemistry Central Journal 2013 7:32

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  46. Content type: Research article

    Plant viruses cause many serious plant diseases and are currently suppressed with the simultaneous use of virucides and insecticides. The use of such materials, however, increases the amounts of pollutants in ...

    Authors: Guang-Ying Huang, Can Cui, Zhi-Peng Wang, Yong-Qiang Li, Li-Xia Xiong, Li-Zhong Wang, Shu-Jing Yu, Zheng-Ming Li and Wei-Guang Zhao

    Citation: Chemistry Central Journal 2013 7:33

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